The ME Lab investigates the cognitive and neural mechanisms that support our ability to retrieve memories for naturalistic events, including autobiographical experiences from our personal past. We are particularly interested in understanding the constructive processes that enable us to edit memories—updating, enhancing, and sometimes distorting our memories.
The ME Lab combines behavioral, patient-based and functional magnetic resonance imaging (fMRI) approaches in young and older adults, and uses novel paradigms, virtual reality, and wearable camera technologies that allow for investigations of memory in real-world environments- thus, maintaining the ecological validity of memories while exerting control over their properties.
The ME Lab has a fully funded graduate student opportunities! Find out more about joining our research team here.
Research
In the ME Lab we take a cognitive neuroscience approach to investigate memories for events, including autobiographical memories for events from our personal past and immersive events that we create in an experimental setting (e.g., controlled encoding of real-world events, virtual reality). Current research in the lab is focused on the following topics:
Reshaping Memories during Retrieval
Memories for the events from our lives are not static, but are prone to changes overtime and due to retrieval. It is this dynamic property of memory for events that contributes to our sense of self over time, allows us to share our memories with others in novel ways and to understand their point of view, enables us to connect the past with the present in order to inform the future, and even to consider what might have or could have been. A main focus in the ME Lab is understanding the neural mechanisms of reactivation-related updating processes in autobiographical memories. In order to examine questions about the accuracy and distortion of naturalistic memories we have created novel paradigms that control for the encoding of events in the real-world using wearable cameras (see below).
Our research has shown that memory reactivation plays a key role in modifying memories (St. Jacques & Schacter, 2013), and is an effective strategy for producing long-lasting modifications in the negative affect associated with memories (De Brigard, Hanna, St. Jacques, & Schacter, 2019). We have also found that reactivation-related modification in memories is reduced in older adults as the result of age-related decreases in the quality of memory reactivation (St. Jacques, Montgomery, & Schacter, 2015). In an fMRI study, we further demonstrated that neural recruitment in a posterior medial network supports both enhancements and distortions in later memories for real-world events, thereby illuminating how memories change over time as a consequence of reactivation (St. Jacques, Olm, & Schacter, 2013). Together these empirical findings provide support for the proposal that adaptive processes that enable memories to be updated with new information can also contribute to distortions in memories (Schacter, Guerin, & St. Jacques, 2011). More recently, we have investigated how memories are reshaped when shifting visual perspective during retrieval.
Visual Perspective in Memories for Events
Having a particular visual perspective or vantage point is an integral aspect of memories for immersive experiences. It is well know that memories for events can be retrieved from multiple visual perspective (i.e., own eyes, observer-like viewpoints), and recent research in our lab using immersive virtual reality has shown that memories can also be formed from multiple visual perspectives (Iriye & St. Jacques, 2021). Adopting alternative visual perspectives when remembering influences early stages of retrieval by increasing the functional connectivity between the anterior hippocampus and precuneus (Iriye & St. Jacques, 2020; see image below).
Our behavioral research has demonstrated that shifts in perspective that occur as memories become more remote are linked to the consistency of episodic details during autobiographical recall (Wardell et al., 2023). Importantly, manipulating visual perspective during memory retrieval also alters the phenomenology and accuracy of subsequent memories (Marcotti & St. Jacques, 2018). These multiple ways that we can retrieve the personal past are supported by common brain regions that contribute to the ability to simulate counterfactual scenarios of how the past could have occurred differently (St. Jacques, Carpenter, Szpunar, & Schacter, 2018), but there are also unique regions that contribute more to perceptual changes to the past that occur when shifting visual perspective (Faul, St. Jacques, De Rosa, Parikh, & De Brigard, 2020). In particular, neural recruitment of the precuneus and angular gyrus support the ability to shift to alternative visual perspectives during remembering (St. Jacques, Szpunar, & Schacter, 2017; see image below). These findings demonstrate that memories are reconstructed in different ways depending on the particular visual perspective adopted, as highlighted in a recent conceptual framework to understand visual perspective in memories for events (St. Jacques, 2019). Understanding whether shifts in visual perspective alter the veridicality of memories has important implications for legal settings (St. Jacques, 2024).
Forming and Retrieving Immersive Memories
Memories for real-world events are immersive experiences that are characterized by our unique viewpoint and three-dimensional nature. For example, using immersive virtual reality, we have investigated how first-person and third-person avatar perspectives influence memory (Iriye & St. Jacques, 2021). Our recent research has focused on developing novel paradigms to bring the real-world into the laboratory and MRI using 360° videos of real-world events presented from a first-person viewpoint using VR head mounted displays and fMRI compatible 3D headsets (Feminella, Peng, & St. Jacques, 2024; Romero, Kalra, & St. Jacques, 2024).
Research questions we’re currently excited about!
What individual differences support the tendency to naturally adopt an own eyes or observer-like perspective, and the the ability to shift between different visual perspectives?
How do the precuneus and angular gyrus uniquely contribute to visual perspective during memory retrieval?
What is the nature of observer-like perspectives in memories? Under what circumstances do we form observer-like perspectives in memories in the real-world?
How does shifting visual perspective during memory retrieval impact the accuracy of memories? Does shifting visual perspective introduce distortions in memories? Can shifting our viewpoint enable us to retrieve additional information about events?
What is the relationship between visual perspective and emotional regulation?
How do properties of real-world experiences (e.g., first-person viewpoint, sense of depth, immersion, dynamism) influence memories?
What are the neural signatures that support immersive memories?
If these questions and others like them excite you too, then you can earn more about joining our research team!
Discover more about our research on our publications page.
The ME Lab hosted a high school student during Spring break via the UAlberta STEM Fellowship. Below is the student’s reflection about their experience in the lab: This spring break I had the incredible opportunity of working at the ME Lab and learning more about research into autobiographical …
We had a productive summer in the lab this year, with several fMRI studies in the works. Additionally, Anna Cuff, an NSERC URSA student in the lab, developed a new project synthesizing functional neuroimaging research on the multifaceted components of perspective in autobiographical memories. Stay tuned for more …
Huge congratulations to Selen Küçüktaş who passed her PhD candidacy exam this past July. To celebrate, we planned a surprise party in her honor! Over the summer we had someone from the Nordic Neurolab come to help install and test our protocol using the VisualSystem HD here at …
We recently published a paper in the journal Memory examining the effect of shifting visual perspective on both episodic and semantic details during autobiographical memory retrieval. This paper was part of a Psychology Honours thesis on the part of Chloe King and Anna Romero. Check out the paper …
Congratulations to Dr. St. Jacques, who is a recipient of the Sloan Research Fellowship in Neuroscience! The Sloan Fellowship awarded to “outstanding early-career faculty who have the potential to revolutionize their fields of study.” The Sloan fellowship will provide research funding in the next two years for the …
Our editorial for the special issue on Visual Perspective in Memory and Imagination will be published in the Journal of Cognitive Psychology in the next issue. Check it out for some exciting new avenues of research in the area! Congratulations to Anna Romero who recently accepted an offer …
Warm welcome to our new and returning lab members! We have a new masters student, Ayça Özgen, from Turkey where she received her BSc in Psychology from Middle East Technical University (METU). Also joining the lab, we have a new Honours Psychology undergraduate student Alannah Nash, a new …
Huge congratulations to Dr. St. Jacques on being awarded a Canadian Research Chair in the Cognitive Neuroscience of Memory! Dr. St. Jacques will have dedicated research time to investigate the neural mechanisms by which we form real-world memories and the role of visual perspective. Congratulations to Psychology Undergraduate …
In April this year, Psychology Undergraduate Honours Students Anna Romero, Chloe King, Azra Panjwani, and Rutuja Kadam, along with Graduate Student Selen Küçüktaş presented at the Royce-Harder Conference. Chloe, Anna, and Rutuja presented posters and Azra was nominated to present a talk at the Brian Harder Honours Symposium. …
Selen Küçüktaş presented a poster at the virtual Cognitive Neuroscience Society #CNS2020 examining how creativity influences visual perspective in autobiographical memories. Check out the poster and presentation. Congratulations to Psychology Undergraduate Honours students Anna Romero and Chloe King for their NSERC USRI! This summer, they will be coding …