{"id":350,"date":"1990-04-01T00:00:00","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"http:\/\/wptest.psych.ualberta.ca\/~cdickson\/wordpress\/?p=350"},"modified":"1990-04-01T00:00:00","modified_gmt":"1970-01-01T00:00:00","slug":"effects-of-p-chlorophenylalanine-and-scopolamine-on-retention-of-habits-in-rats","status":"publish","type":"post","link":"https:\/\/sites.psych.ualberta.ca\/brainrhythmslab\/effects-of-p-chlorophenylalanine-and-scopolamine-on-retention-of-habits-in-rats\/","title":{"rendered":"Effects of p-chlorophenylalanine and scopolamine on retention of habits in rats"},"content":{"rendered":"<p>PMID: <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2140608' title=''>2140608<\/a><\/a><\/p>\n<p>Vanderwolf CH, Dickson CT, Baker GB<\/p>\n<p>Pharmacol. Biochem. Behav. 1990 Apr;35(4):847-53<\/p>\n<h2>Abstract<\/h2>\n<p><p>Rats were trained on a conventional maze test or on a swim-to-platform test. Retention of swim-to-platform performance 7 days later was severely impaired by posttraining treatment with a combination of p-chlorophenylalanine (PCPA) and scopolamine although neither drug alone had any effect. Retention of the maze habit was moderately impaired by scopolamine alone and severely impaired by a combination of scopolamine and PCPA, but was unaffected by PCPA alone. Polygraphic recordings confirmed previous reports that a combination of PCPA and scopolamine can abolish neocortical low voltage fast activity and hippocampal rhythmical slow activity. Combined blockade of central cholinergic and serotonergic neurotransmission in rats may provide a useful animal model of Alzheimer&#8217;s disease.<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>PMID: 2140608 Vanderwolf CH, Dickson CT, Baker GB Pharmacol. Biochem. Behav. 1990 Apr;35(4):847-53 Abstract Rats were trained on a conventional maze test or on a swim-to-platform test. Retention of swim-to-platform performance 7 days later was severely impaired by posttraining treatment with a combination of p-chlorophenylalanine (PCPA) and scopolamine although neither drug alone had any effect. [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-350","post","type-post","status-publish","format-standard","hentry","category-uncategorized","post-preview"],"_links":{"self":[{"href":"https:\/\/sites.psych.ualberta.ca\/brainrhythmslab\/wp-json\/wp\/v2\/posts\/350","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.psych.ualberta.ca\/brainrhythmslab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.psych.ualberta.ca\/brainrhythmslab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.psych.ualberta.ca\/brainrhythmslab\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.psych.ualberta.ca\/brainrhythmslab\/wp-json\/wp\/v2\/comments?post=350"}],"version-history":[{"count":0,"href":"https:\/\/sites.psych.ualberta.ca\/brainrhythmslab\/wp-json\/wp\/v2\/posts\/350\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.psych.ualberta.ca\/brainrhythmslab\/wp-json\/wp\/v2\/media?parent=350"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.psych.ualberta.ca\/brainrhythmslab\/wp-json\/wp\/v2\/categories?post=350"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.psych.ualberta.ca\/brainrhythmslab\/wp-json\/wp\/v2\/tags?post=350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}