{"id":729,"date":"2021-12-15T16:35:27","date_gmt":"2021-12-15T23:35:27","guid":{"rendered":"https:\/\/sites.psych.ualberta.ca\/SynAD\/?page_id=729"},"modified":"2022-04-20T13:28:09","modified_gmt":"2022-04-20T19:28:09","slug":"synad-outputs","status":"publish","type":"page","link":"https:\/\/sites.psych.ualberta.ca\/SynAD\/synad-outputs\/","title":{"rendered":"SynAD Outputs"},"content":{"rendered":"

\"\"The principal SynAD outputs are the 64 peer-reviewed small grants we have awarded to promote ADRD research at the University of Alberta. As described on the SynAD Activities page, the grants are awarded in three categories: Catalyst Research, Small Equipment, and Trainee Support. Some of these awards have begun to produce longer-term (or secondary) outputs ranging from scientific products to public acknowledgments. We are sorting these into three categories: (1) notable recognitions and related activities, (2) publications and other written reports, and (3) conference and other formal presentations. The SynAD team is continuously collecting information pertaining to these emerging downstream outputs.<\/span><\/p>\n

SynAD Recognitions<\/span><\/strong><\/h2>\n

SynAD grantee (Graduate Student Trainee Grant) Laszlo Locskai (Biological Sciences, Science) has been awarded a CIHR CGS-D Doctoral Scholarship. This prestigious award will allow Laszlo to continue his research linking TBI with seizures and tauopathy in a zebrafish model under the supervision of Dr. Ted Allison.<\/span><\/p>\n

SynAD member Simonetta Sipione (Department of Pharmacology and Neuroscience and Mental Health Institute) received a new grant from CIHR entitled: The role of glycosphingolipids in the secretion and clearance of EVs in brain health and disease<\/em>, based on preliminary studies funded by a SynAD Catalyst Grant award from 2019-2020. She also received matching funds from a GlycoNET grant entitled Modulatory and therapeutic roles of gangliosides in neurodegeneration and neuroinflammation<\/em>, based in part on data generated with SynAD support (2020-2021).<\/span><\/p>\n

SynAD grantee (Post Doctoral Fellow Trainee Grant) Richard Kanyo (Biological Sciences, Science) has published two research papers receiving media attention:<\/span>
\nhttps:\/\/globalnews.ca\/video\/7659130\/health-matters-solving-medical-mysteries-and-preventing-dementia\/<\/a><\/strong>
\nhttps:\/\/www.ualberta.ca\/folio\/2021\/06\/early-exposure-to-cannabis-compounds-reduces-later-neural-activity-in-zebrafish-study.html<\/a><\/strong><\/p>\n

SynAD support to Marek Michalak (Biochemistry; Small Equipment Grant) has been reported as instrumental in supporting research on membrane associated chaperones and their role in protein folding and protein folding disease, including Alzheimer\u2019s and other neurodegenerative diseases. This resulted in several recent research publications and has helped secure end MS Scholarship funding for graduate student Tautvydas Paskevicius.<\/span><\/p>\n

Trevor Steve (Medicine, Neurology) was named a Future Leader in Canadian Brain Research. For this honour, he received a $100,000 special grant award from Brain Canada to further his research in hippocampal biomarkers of Alzheimer’s disease. Trevor Steve received a SynAD catalyst award in 2018-2019.<\/span><\/p>\n

Sue-Ann Mok (Biochemistry) was named a Future Leader in Canadian Brain Research. For this honour, she received a $100,000 special grant award from Brain Canada to further her research in protein folding disorders in Alzheimer’s disease. Sue-Ann Mok’s PhD student (Lion Budrass) received the 2020-2021 NMHI-SynAD Studentship for Research in Alzheimer’s Disease and Related Dementias.<\/span><\/p>\n

Satyabrata Kar (Centre for Prions and Protein Folding Diseases) received a new grant from CIHR: Biodegradable Acidic Nanoparticles <\/span>Attenuate \u03b2-amyloid Aggregation\/Toxicity: Potential Implications in the Treatment of Alzheimer\u2019s Disease Pathology<\/em>.\u00a0<\/i>This grant is based in part on his SynAD Catalyst Grant award from 2020-2021. His Co-Investigators (H. Wille and F. Giuliani) are also co-recipients of previous SynAD awards.\u00a0<\/span><\/p>\n

SynAD member David Westaway leads a team receiving a large new grant from the Canada Foundation for Innovation to fund promising new initiatives in Alberta for advancing our knowledge about protein misfolding and ADRD. See summary of Dr. Westaway’s new research funding.<\/a><\/strong><\/span><\/p>\n

SynAD members Roger Dixon and David Westaway were co-organizers (along with colleagues from UCalgary and ULethbridge) of an international conference sponsored by Campus Alberta Neuroscience in May 2021. The virtual conference,\u00a0Promoting Healthy Brain Aging and Preventing Dementia: Research and Translation<\/i>, featured international, national and Alberta-based speakers.<\/span><\/p>\n

SynAD member Jack Jhamandas (Medicine\/Neurology) announces his latest programmatic contribution to developing a small-molecule AD therapy drug that can be readied for human clinical trials. This work was funded in part by a SynAD grant.<\/span>
\nhttps:\/\/www.ualberta.ca\/medicine\/momentum\/2020\/momentum-stories-2020\/2020\/may\/new-piece-of-alzheimers-puzzle-found.html<\/a><\/strong><\/p>\n

SynAD member Roger Dixon has published several recent editions of the Canadian Consortium on Neurodegeneration in Aging (CCNA) Biomarkers in ADRD Team newsletters. CCNA is a partner of SynAD.
\n<\/span>Dixon, R.A., & Bellec, P. (2021, June). CCNA\/CCNV Team 9 Bulletin: Biomarkers of aging and neurodegeneration. Edmonton\/Montr\u00e9al: Canadian Consortium on Neurodegeneration in Aging.<\/a>
\n<\/span>Dixon, R.A., & Bellec, P. (2020, May). CCNA\/CCNV Team 9 Bulletin: Biomarkers of aging and neurodegeneration. Edmonton\/Montr\u00e9al: Canadian Consortium on Neurodegeneration in Aging.<\/a>
\nDixon, R.A., & Bellec, P. (2020, December). CCNA\/CCNV Team 9 Bulletin: Biomarkers of aging and neurodegeneration. Edmonton\/Montr\u00e9al: Canadian Consortium on Neurodegeneration in Aging.<\/a><\/strong><\/p>\n

SynAD member and grantee, Jack Jhamandas (Medicine\/Neurology, NMHI), has published groundbreaking research on Alzheimer’s disease.\u00a0<\/span>
\nhttps:\/\/www.folio.ca\/new-piece-of-alzheimers-puzzle-found\/?fbclid=IwAR1pPOsPrdHmXB4Zz8kJm1Q0V8GY7rcunGeGZeEbZAkJ-s-a3-5vVSnHKGE<\/a><\/span><\/strong><\/p>\n

SynAD members Roger Dixon and Richard Camicioli are PIs of the Canadian Consortium on Neurodegeneration in Aging (CCNA). The CCNA has now received funding (from CIHR and partners) for its second 5-year phase.
\nhttps:\/\/www.ualberta.ca\/science\/science-news\/2019\/july\/dementia-prevention-research-funding<\/a><\/strong><\/span><\/p>\n

SynAD Co-Investigator, Valerie Sim, received press attention for the recent PRION 2019: Emerging Concepts conference held in Edmonton in May 2019.<\/span>
\nhttps:\/\/edmontonjournal.com\/news\/local-news\/researchers-share-strategies-to-solve-mysterious-diseases-at-edmonton-conference<\/a><\/strong><\/p>\n

The SynAD program was the subject of a press release by the University of Alberta Faculty of Medicine and Dentistry.\u00a0 This release was published on the FoMD website and then re-published on the Faculty of Science website.<\/span><\/div>\n
\n

https:\/\/www.ualberta.ca\/medicine\/news\/2019\/april\/1-million-catalyst-grant-sparks-alzheimers-research-collaboration-at-the-u-of-a<\/a><\/strong><\/p>\n

SynAD members Roger A. Dixon (Psychology), Liang Li (Chemistry), and Richard Camicioli (Neurology) received public press recognition for their recent collaborative work in biomarkers of ADRD.<\/span>
\nhttps:\/\/www.folio.ca\/discovery-brings-saliva-test-for-alzheimers-disease-one-step-closer\/<\/a><\/strong><\/p>\n<\/div>\n

SynAD Publications<\/span><\/strong><\/h2>\n

Abdullah, T.M., Whatmore, J.,\u00a0<\/sup>Bremer, E.,\u00a0<\/sup>Slibinskas, R., Michalak, M., & Eggleton, E. (2021). Endoplasmic reticulum stress-induced release and binding of calreticulin from human ovarian cancer cells. Cancer Immunology, Immunotherapy. https:\/\/doi.org\/10.1007\/s00262-021-03072-6<\/a><\/strong><\/span><\/p>\n

Alyenbaawi, H., Kanyo, R., Locskai, L.F., Kamali-Jamil, R., DuVal, M.G., Bai, Q., Wille, H., Burton, E.A., & Allison, W.T. (2021). Seizures are a druggable mechanistic link between TBI and subsequent tauopathy. eLife. https:\/\/doi.org\/10.7554\/eLife.58744<\/a><\/strong><\/span><\/p>\n

Anand, B.G., Wu, Q., Karthivashan, G., Shejale, K.P., Amidian, S., Wille, H., & Kar, S. (2021). Mimosine functionalized gold nanoparticles (Mimo-AuNPs) suppress \u03b2-amyloid aggregation and neuronal toxicity. Bioactive Materials. https:\/\/dx.doi.org\/10.1016\/j.bioactmat.2021.04.029<\/a><\/strong><\/span><\/p>\n

Budrass, L., Fahlman, R.P., & Mok, S.-A. (2021). Deciphering network crosstalk: The current status and potential of miRNA regulatory networks on the HSP40 molecular chaperone network. Frontiers in Genetics. https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2021.689922<\/a><\/strong><\/span><\/p>\n

Caballero, H.S., McFall, G.P., Wiebe, S., & Dixon, R.A. (2021). Integrating three characteristics of executive function in non-demented aging: Trajectories, classification, and biomarker predictors. Journal of the International Neuropsychological Society. https:\/\/doi.org\/10.1017\/S1355617720000703<\/a><\/strong><\/span><\/p>\n

Caballero, H.S., McFall, G.P., Zheng, Y., & Dixon, R.A. (2021). Data-driven approaches to executive function performance and structure in aging: Integrating person-centered analyses and machine learning risk prediction. Neuropsychology. https:\/\/doi.org\/10.1037\/neu0000775<\/a><\/strong><\/span><\/p>\n

Cao, B., Liu, Y.S., Selvitella, A., Librenza-Garcia, D., Passos, I.C., Sawalha, J., Ballester, P., Chen, J., Dong, S., Wang, F., Kapczinski, F., Dursun, S.M., Li, X.-M., Grenier, R., & Greenshaw, A. (2021). Differential power of placebo across major psychiatric disorders: A preliminary meta-analysis and machine learning study. Scientific Reports. https:\/\/doi.org\/10.1038\/s41598-021-99534-z<\/a><\/strong><\/span><\/p>\n

Castle, A.R., Daude, N., Gilch, S., & Westaway, D. (2019). Application of high-throughput, capillary-based Western analysis to modulated cleavage of the cellular prion protein. Journal of Biological Chemistry. https:\/\/doi.org\/10.1074\/jbc.RA118.006367<\/a><\/strong><\/span><\/p>\n

Daude, N., Kim, C., Kang, S.G., Eskandari-Sedighi, G., Haldiman, T., Yang, J., Fleck, S.C., Gomez-Cardona, E., Han, Z.Z., Borrego-Ecija, S., Wohlgemuth, S., Julien, O., Wille, H., Molina-Porcel, L., Gelpi, E., Safar, J.G., & Westaway, D. (2020). Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation. Acta Neuropathology. https:\/\/doi.org\/10.1007\/s00401-020-02148-4<\/a><\/strong><\/span><\/p>\n

Grant, P., Kumar, J., Kar, S., & Overduin, M. (2021). Effects of specific inhibitors for CaMK1D on a primary neuron model for Alzheimer’s disease. Molecules. https:\/\/doi.org\/10.3390\/molecules26247669<\/a><\/strong><\/span><\/p>\n

Groenendyk, J., Wang, Q., Wagg, C., Lee, D., Robinson, A., Barr, A., Light, P., Lopaschuk, G.L., Agellon L.B., & Michalak, M. (2020). Selective enhancement of cardiomyocyte metabolic efficiency results in a pernicious heart condition. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0236457<\/a><\/strong><\/span><\/p>\n

Jabbari-zadeh, F., Cao, B., Stanley, J.A., Liu, Y., Wu, M.-J., Tannous, J., Lopez, M., Sanches, M., Mwangi, B., Zunta-Soares, G.B., & Soares, J.C. (2021). Evidence of altered metabolism of cellular membranes in bipolar disorder comorbid with post-traumatic stress disorder. Journal of Affective Disorders. https:\/\/doi.org\/10.1016\/j.jad.2021.04.011<\/a><\/strong><\/span><\/p>\n

Kanyo, R., Amin, M.R., Locskai, L.F., Bouvier, D.D., Olthuis, A.M., Allison, W.T., & Ali, D.W. (2021). Medium-throughput zebrafish optogenetic platform identifies deficits in subsequent neural activity following brief early exposure to cannabidiol and \u0394\u2079-tetrahydrocannabinol. Scientific Reports. https:\/\/doi.org\/10.1038\/s41598-021-90902-3<\/a><\/strong><\/span><\/p>\n

Kanyo, R., Leighton, P.L.A., Neil, G.J., Locskai, L.F., & Allison, W.T. (2020). Amyloid-\u03b2 precursor protein mutant zebrafish exhibit seizure susceptibility that depends on prion protein. Experimental Neurology. https:\/\/doi.org\/10.1016\/j.expneurol.2020.113283<\/a><\/strong><\/span><\/p>\n

Kanyo, R., Wang, C.K., Locskai, L.F., Li, J., Allison, W.T., & Kurata, H.T. (2020). Functional and behavioral signatures of Kv7 activator drug subtypes. Epilepsia. https:\/\/doi.org\/10.1111\/epi.16592<\/a><\/strong><\/span><\/p>\n

Lucena, D.D., Kruse, N., Thune, K., Schmitz, M., Villar-Pique, A., da Cunha, E.G., Hermann, P., Perez, O.L., Benito, P.A., Ladogana, A., Laqra, M.C., Vidal, E., Riggert, J., Pineau, H., Sim, V., Zetterberg, H., Blennow, K., del Rio, J.A., Moreno, A.M., Espinosa, J.C., Torres, J.M., Mollenhauer, B., Ferrer, I., Zerr, I., & Llorens, F. (2021). TREM2 expression in the brain and biological fluids in prion diseases. Acta Neuropathologica. https:\/\/doi.org\/10.1007\/s00401-021-02296-1<\/a><\/strong><\/span><\/p>\n

Moulton, M.J., Barish, S., Ralhan, I., Chang, J., Goodman, L.D., Harland, J.G., Marcogliese, P.C., Johansson, J.O., Ioannou, M.S., & Bellen, H.J. (2021). Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer\u2019s disease-associated genes. PNAS. https:\/\/doi.org\/10.1073\/pnas.2112095118<\/a><\/strong><\/span><\/p>\n

Paskevicius, T., Jung, J., Pujol, M., Eggleton, P., Qin, W., Robinson, A., Gutowski, N., Holley, J., Smallwood, M., Newcombe, J., Zochodne, D., Chen, X.-Z., Tang, J., Kraus, A., Michalak, M., & Agellon, L.B. (2020). The Fabp5\/calnexin complex is a prerequisite for sensitization of mice to experimental autoimmune encephalomyelitis. FASEB Journal. <\/em>https:\/\/doi.org\/10.1096\/fj.202001539RR<\/a><\/strong><\/span><\/p>\n

Pineau, H., & Sim, V.L. (2020). POSCAbilities: The application of the prion organotypic slice culture assay to neurodegenerative disease research. Biomolecules. https:\/\/doi.org\/10.3390\/biom10071079<\/a><\/strong><\/span><\/p>\n

Ralhan, I., Chang, C.L., Lippincott-Schwartz, J., & Ioannou, M.S. (2021). Lipid droplets in the nervous system. Journal of Cell Biology. https:\/\/doi.org\/10.1083\/jcb.202102136<\/a><\/strong><\/span><\/p>\n

Sawalha, J., Cao, L., Chen, J., Selvitella, A., Liu, Y., Yang, C., Li, X., Zhang, X., Sun, J., Zhang, Y., Zhao, L., Cui, L., Zhang, Y., Sui, J., Grenier, R., Li, X.-M., Greenshaw, A., Li, T., & Cao, B. (2021). Individualized identification of first-episode bipolar disorder using machine learning and cognitive tests. Journal of Affective Disorders. https:\/\/doi.org\/10.1016\/j.jad.2020.12.046<\/a><\/strong><\/span><\/p>\n

Sipione, S., Monyror, J., Galleguillos, D., Steinberg, N., & Kadam, V. (2020). Gangliosides in the brain: Physiology, pathophysiology and therapeutic applications. Frontiers in Neuroscience. https:\/\/doi.org\/10.3389\/fnins.2020.572965<\/a><\/strong><\/span><\/p>\n

Soudy, R., Kimura, R., Patel, A., Fu, W., Kaur, K., Westaway, D., Yang, J., & Jhamandas, J. (2019). Short amylin receptor antagonist peptides improve memory deficits in Alzheimer\u2019s disease mouse model. Scientific Reports. https:\/\/doi.org\/10.1038\/s41598-019-47255-9<\/a><\/strong><\/span><\/p>\n

Sufian, M.S., Amin, M.R., Kanyo, R., Allison, W.T., & Ali, D.W. (2019). CB1 and CB2 receptors play differential roles in early zebrafish locomotor development. Journal of Experimental Biology. https:\/\/doi.org\/10.1242\/jeb.206680<\/a><\/strong><\/span><\/p>\n

Wang, Q., Groenendyk, J., Paskevicius, T., Qin, W., Kor, K.C., Liu, Y., Hiess, F., Knollmann, B.C., Chen, S.R.W., Tang, J., Chen, X.-Z., Agellon, L.B., & Michalak, M. (2019). Two pools of IRE1\u03b1 in cardiac and skeletal muscle cells. FASEB Journal. https:\/\/doi.org\/10.1096\/fj.201802626R<\/a><\/strong><\/span><\/p>\n

Wang, Q., Paskevicius, T., Filbert, A., Qin, W., Kim, H.J., Chen, X.Z., Tang, J., Dacks, J.B., Agellon, L.B., & Michalak, M. (2020). Phylogenetic and biochemical analysis of calsequestrin structure and association of its variants with cardiac disorders. Scientific Reports. https:\/\/doi.org\/10.1038\/s41598-020-75097-3<\/a><\/strong><\/span><\/p>\n

Wang, Y., Wu, Q., Anand, B.G., Karthivashan, G., Phukan, G., Yang, J., Thinakaran, G., Westaway, D., & Kar, S. (2020). Significance of cytosolic cathepsin D in Alzheimer\u2019s disease pathology: Protective cellular effects of nanoparticles against \u03b2-amyloid toxicity. Neuropathology and Applied Neurobiology. https:\/\/doi.org\/10.1111\/nan.12647<\/a><\/strong><\/span><\/p>\n

Watson, A., de Almeida, M., Dittmann, N.L., Li, Y., Torabi, P., Footz, T., Vetere, G., Galleguillos, D., Sipione, S., Cardona, A.E., & Voronova, A. (2021). Fractalkine signaling regulates oligodendroglial cell genesis from SVZ precursor cells. Stem Cell Reports. https:\/\/doi.org\/10.1016\/j.stemcr.2021.06.010<\/a><\/strong><\/span><\/p>\n

Wu, Q., Cortez, L., Kamali-Jamil, R., Sim, V., Wille, H., & Kar, S. (2021). Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer’s disease pathology. Disease Models & Mechanisms. https:\/\/doi.org\/10.1242\/dmm.048929<\/a><\/strong><\/span><\/p>\n

Galleguillos, D., Wang, Q., Steinberg, N., Shrivastava, G., Dhami, K., Rubinstein, K., Giuliani, F., Churchward, M., Power, C., Todd, K., & Sipione, S. (2020). Anti-inflammatory role of GM1 and modulatory effects of gangliosides on microglia functions. Preprint. BioRxiv. https:\/\/doi.org\/10.1101\/2020.03.04.975862<\/a><\/strong><\/span><\/p>\n

Moulton, M.J., Barish, S., Ralhan, I., Chang, J., Goodman, L.D., Harland, J.G., Marcogliese, P.C., Johansson, J.O., Ioannou, M.S., & Bellen, H.J. (2021). Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer\u2019s disease-associated genes. Preprint. BioRxiv. https:\/\/doi.org\/10.1101\/2021.03.03.433580<\/a><\/strong><\/span><\/p>\n

Talarico, F., Chakravarty, S., Liu, Y.S., Greenshaw, A., Passos, I.C., & Cao, B. (2020). Psychiatric side effects induced by chloroquine and hydroxychloroquine: A systematic review of case reports and population studies. Preprint. MedRxiv.\u00a0 https:\/\/doi.org\/10.1101\/2020.10.05.20207423<\/a><\/strong><\/span><\/p>\n

Viveiros, A., Kadam, V., Morales, L.C., Pink, D., Rieger, A.M., Sipione, S., & Posse de Chaves, E. (2021). A method to study extracellular vesicles secreted in vitro by cultured cells with minimum sample processing and extracellular vesicle loss. Preprint. BioRxiv.\u00a0 https:\/\/www.biorxiv.org\/content\/10.1101\/2021.06.18.447964v1<\/a><\/strong><\/span><\/p>\n

Alam, M. et al. Effect of temperature on APP processing in cultured astrocytes and its potential implication in Alzheimer\u2019s disease pathology. Submitted for Publication.\u00a0<\/span><\/p>\n

Bohn, L., McFall, G.P., Gee, M., Postuma, R.B., Dixon, R.A., Camicioli, R.C. Application of the Montr\u00e9al Parkinson Risk of Dementia Rating Scale to a geriatric Parkinson’s disease cohort. Submitted for Publication.<\/span><\/p>\n

Paul, P.S., Cho, J.-Y., Wu, Q., Grabovac, E., Wille, H., Kulka, M., & Kar, S. Unconjugated nanoparticles attenuate temperature-dependent \u03b2-amyloid aggregation and protect neurons against toxicity: Implications for Alzheimer\u2019s disease pathology. Submitted for Publication.<\/span><\/p>\n

Castle, A.R. et al. Cell surface proteins and PrP endoproteolysis. Manuscript.\u00a0<\/span><\/p>\n

Kadam, V., Monyror, J., Morales, L.C., Huang, J., Maguire, A., Ordonez, D., Samuelson, S., Posse de Chaves, E., Sipione, S. Ganglioside GM1 promotes neuronal secretion of mHTT by extracellular vesicles. Manuscript.\u00a0<\/span><\/p>\n

McFall, G.P., Bohn, L., Drouin, S.M., Gee, M., Han, W., Li, L., Camicioli, R., Dixon, R.A. Towards identifying multi-modal predictors of incipient dementia in Parkinson’s disease: A machine learning analysis. Manuscript.<\/span><\/p>\n

Schmaus, A. et al. Retromer proteins and Tau. Manuscript.\u00a0<\/span><\/p>\n

SynAD Presentations<\/span><\/strong><\/h2>\n

Kuru, L., Cortez, L., Nemani, S., Pineau, H., & Sim, V. (2021, October). A new method for the separation and characterization of amyloid beta and tau aggregates in human brain samples. Poster Presentation at Virtual Faculty of Medicine & Dentistry Summer Students\u2019 Research Day, University of Alberta.<\/span><\/p>\n

Sim, V. (2021, October). Strain-specific pathology and spread in prion organotypic slice culture assay. Presentation at Virtual CJD Foundation Family Conference.<\/span><\/p>\n

Pineau, H., & Sim, V.L. (2021, June). Investigating prion strain tropism in whole brain organotypic slice culture. Poster Presentation at Virtual Canadian Society for Molecular Biosciences Annual Conference on Protein Homeostasis.<\/span><\/p>\n

Bohn, L., McFall, G.P., Gee, M., Dixon, R.A., & Camicioli, R. (2021, May). Does the Montreal Parkinson Risk of Dementia Rating Scale predict dementia in a geriatric Parkinson’s disease cohort? Presentation at Campus Alberta Neuroscience: Conference on Promoting Healthy Brain Aging and Preventing Dementia (Research and Translation).<\/span><\/p>\n

Caballero, H.S., McFall, G.P., Zheng, Y., & Dixon, R.A. (2021, May). Data-driven approaches to executive function performance and structure in aging: Integrating person-centered analyses and machine learning risk prediction. Presentation at Campus Alberta Neuroscience: Conference on Promoting Healthy Brain Aging and Preventing Dementia (Research and Translation).<\/span><\/p>\n

Heal, M., McFall, G.P., Vergote, D., & Dixon, R.A. (2021, May). Bridging Integrator 1 (BIN1, rs6733839) and sex are moderators of vascular health predictions of memory aging trajectories. Presentation at Campus Alberta Neuroscience: Conference on Promoting Healthy Brain Aging and Preventing Dementia (Research and Translation).<\/span><\/p>\n

Kluger, F.E., Oladimeji, D.M., Tan, Y., Brown, N.R., & Caplan, J.B. (2021, May). Mnemonic training for older adults: Alternatives to the method of loci. Presentation at Campus Alberta Neuroscience: Conference on Promoting Healthy Brain Aging and Preventing Dementia (Research and Translation).<\/span><\/p>\n

McFall, G.P., Bohn, L., Gee, M., Drouin, S.M., Han, W., Li, L., Camicioli, R., & Dixon, R.A. (2021, May). Machine learning analyses identify multi-modal predictors of incipient dementia in Parkinson’s disease. Presentation at Campus Alberta Neuroscience: Conference on Promoting Healthy Brain Aging and Preventing Dementia (Research and Translation).<\/span><\/p>\n

Ralhan, I., Chang, J., & Ioannou, M.S. (2021, May). Investigating the role of lysosomal exocytosis in lipid release from neurons during oxidative stress. Poster Presentation at Virtual Department of Physiology Research Day, University of Alberta, Edmonton, Alberta.<\/span><\/p>\n

Heal, M., McFall, G.P., Vergote, D., & Dixon, R.A. (2021, March). Bridging Integrator 1 (BIN1, rs6733839) and sex are moderators of vascular health predictions of memory aging trajectories. Presentation at 22nd Annual Neuroscience and Mental Health Institute Research Day.<\/span><\/p>\n

McFall, G.P., Caballero, S., Vergote, D., Heal, M., Andrews, S.J., Jhamandas, J.H., Westaway, D., & Dixon, R.A. (2021, March). Integrating a new genomic data base in the Victoria Longitudinal Study: Brain aging and neurodegenerative disease variants for risk classification and trajectory prediction. Presentation at 22nd Annual Neuroscience and Mental Health Institute Research Day.<\/span><\/p>\n

Ralhan, I., Chang, J., & Ioannou, M.S. (2021, February). Investigating the role of lysosomal exocytosis in lipid release from neurons during oxidative stress. Poster Presentation at Virtual Department of Cell Biology Research Day, University of Alberta, Edmonton, Alberta.<\/span><\/p>\n

Monyror, J., Kadam, V., Alpaugh, M., Morales, L.C., Galleguillos, D., Stenlund, M., … Posse de Chaves, E., Fahlman, R., & Sipione, S. (2021, January). An unbiased proteomics screen to identify neuroprotective pathways elicited by ganglioside GM1 in Huntington\u2019s disease. Poster Presentation at Society for Neuroscience Connectome (Virtual Online Conference).<\/span><\/p>\n

Sipione, S. (2020, December). Invited Speaker at Alberta Prion Research Institute Symposium.<\/span><\/p>\n

Sim, V. (2020, November). Assessing the strain-phenotype relationship in prion and prion-like diseases. Presentation at Alberta Prion Research Institute 2020 Virtual Scientific Meeting.<\/span><\/p>\n

Sipione, S. (2020, November). Gangliosides in neurodegeneration and neuroinflammation. Invited Speaker at Canadian Glycomics Network Virtual Seminar Series (National).<\/span><\/p>\n

Caballero, S., McFall, G.P., Gee, M., Nelles, K., Burt, J., Dixon, R.A., & Camicioli, R. (2020, October). Fluctuating cognition in Parkinson’s disease and dementia. Poster Presentation at Virtual CCNA Science Day Conference.<\/span><\/p>\n

Sipione, S. (2020, July). Gangliosides for Huntington disease and beyond. Presentation at Neuroscience and Mental Health Institute Web Conference.<\/span><\/p>\n

Sipione, S. (2020, July). Invited Speaker at Innovation & Insights Symposium.<\/span><\/p>\n

Caballero, H.S., McFall, G.P., Gee, M., Nelles, K., Burt, J., MacDonald, S.W.S., Dixon, R.A., & Camicioli, R. (2020, March). Fluctuating cognition in neurodegenerative disease: Comparing reaction time mean rate and inconsistency. Poster Presentation at 21st Annual Neuroscience and Mental Health Institute Research Day, Edmonton, AB.<\/span><\/p>\n

Sipione, S. (2020, February). Invited Speaker at Alberta Glycomics Group.<\/span><\/p>\n

Jhamandas, J. (2020, January). Quest for a novel therapy against Alzheimer\u2019s disease. Presentation at Neuroscience Rounds, University of Alberta.<\/span><\/p>\n

Dixon, R.A. (2019, October). Can precision prevention targets be identified via data-driven analyses of asymptomatic trajectories? Keynote Address at International Research Network on Dementia Prevention Conference, Sydney, Australia.<\/span><\/p>\n

Dixon, R.A. (2019, April). Exploring how bio-signals shape trajectories of brain and cognitive aging: Implications for Alzheimer’s disease risk and protection. Invited Address at Beckman Institute, University of Illinois, USA.<\/span><\/p>\n

Dixon, R.A. (2019, March). On the hunt for bio-signals predicting trajectories toward or away from Alzheimer\u2019s disease. Keynote Address at Aging and Brain Health: Prevention and Early Detection of Dementia, Toronto, ON.<\/span><\/p>\n

Alam, M. et al. (2019). Effect of temperature on APP processing in cultured astrocytes and its potential implication in Alzheimer\u2019s. Poster Presentation at Psychiatry Department Research Day, University of Alberta.<\/span><\/p>\n

Grant, P., Kumar, J., Kar, S., & Overduin, M. (2019). Targeting a novel kinase driving late onset Alzheimer\u2019s disease. Poster Presentation at Department of Biochemistry Scientific Retreat, Banff, AB.<\/span><\/p>\n

Kadam, V., \u2026 Posse de Chaves, E., & Sipione, S. (2019). Effects of gangliosides on the secretion of extracellular vesicles in normal and Huntington’s disease cells. Poster Presentation at Canadian Cytometry and Microscopy Symposium, Edmonton, AB.<\/span><\/p>\n

Kadam, V., \u2026 Posse de Chaves, E., & Sipione, S. (2019). Ganglioside GM1 promotes the secretion of extracellular vesicles carrying mutant huntingtin. Poster Presentation at Pharmacology Research Day, Edmonton, AB.<\/span><\/p>\n

Kanyo, R., … Allison, W.T. (2019). Prp1 is necessary for seizure-susceptibility in appa zebrafish knockout and new in vivo anti-convulsants. Poster Presentation at PRION 2019 International Congress, Edmonton, AB. Abstract published doi:10.1080\/19336896.2019.1615197<\/span><\/p>\n

Michalak, M. (2019). Lecture Presentation, 3rd<\/sup> International Hawaii Cardiovascular Symposium, Honolulu, Hawaii.<\/span><\/p>\n

Michalak, M. (2019). Lecture Presentation, Hubei University of Technology, Wuhan, China.<\/span><\/p>\n

Michalak, M. (2019). Research Presentation at the 13th International Calreticulin Workshop, Montreal, Canada<\/span><\/p>\n

Viveiros, A., & Posse de Chaves, E. (2019). Autophagy and EV secretion in the prion-like spreading of amyloid-beta. Presentation at Pharmacology Research Day, Edmonton, AB.<\/span><\/p>\n

Wu, Q. et al. (2019). Characterization of exosomes-derived from cholesterol accumulated astrocytes and its significance in AD. Poster Presentation at Department of Medicine Research Day, Edmonton, AB.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

The principal SynAD outputs are the 64 peer-reviewed small grants we have awarded to promote ADRD research at the University of Alberta. As described on the SynAD Activities page, the grants are awarded in three categories: Catalyst Research, Small Equipment, and Trainee Support. Some of these awards have begun to produce longer-term (or secondary) outputs…<\/p>\n

Read More<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-729","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.psych.ualberta.ca\/SynAD\/wp-json\/wp\/v2\/pages\/729","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.psych.ualberta.ca\/SynAD\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.psych.ualberta.ca\/SynAD\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.psych.ualberta.ca\/SynAD\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.psych.ualberta.ca\/SynAD\/wp-json\/wp\/v2\/comments?post=729"}],"version-history":[{"count":45,"href":"https:\/\/sites.psych.ualberta.ca\/SynAD\/wp-json\/wp\/v2\/pages\/729\/revisions"}],"predecessor-version":[{"id":1003,"href":"https:\/\/sites.psych.ualberta.ca\/SynAD\/wp-json\/wp\/v2\/pages\/729\/revisions\/1003"}],"wp:attachment":[{"href":"https:\/\/sites.psych.ualberta.ca\/SynAD\/wp-json\/wp\/v2\/media?parent=729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}